Seek and destroy: targeted adeno-associated viruses for gene delivery to hepatocellular carcinoma
نویسندگان
چکیده
منابع مشابه
Seek and Destroy: Targeted Resource Depletion Attacks on Sensor Networks
Denial of service attacks can be catastrophic in wireless sensor networks. Typical denial of service attacks consist of either communications jamming or resource depletion through forcing continuous stimuli and communication between motes on the network. Localization is another interesting challenge in the world of sensor networks. Many applications utilizing sensor networks require that the an...
متن کاملLactosylated liposomes for targeted delivery of doxorubicin to hepatocellular carcinoma
BACKGROUND N-lactosyl-dioleoylphosphatidylethanolamine (Lac-DOPE) was synthesized and evaluated as a liver-specific targeting ligand via asialoglycoprotein receptors for liposomal delivery of doxorubicin. METHODS Lactosylated liposomes encapsulating calcein (Lac-L-calcein) or doxorubicin (Lac-L-DOX) composed of egg phosphatidylcholine, cholesterol, monomethoxy polyethylene glycol 2000-distear...
متن کاملTargeted gene delivery to vascular tissue in vivo by tropism-modified adeno-associated virus vectors.
BACKGROUND Gene therapy offers an unprecedented opportunity to treat diverse pathologies. Adeno-associated virus (AAV) is a promising gene delivery vector for cardiovascular disease. However, AAV transduces the liver after systemic administration, reducing its usefulness for therapies targeted at other sites. Because vascular endothelial cells (ECs) are in contact with the bloodstream and are h...
متن کاملHepatocellular carcinoma cell-specific peptide ligand for targeted drug delivery.
Hepatocellular carcinoma is the fourth leading cause of cancer death worldwide. Novel treatment strategies derived from increased knowledge of molecular oncology are constantly being developed to cure this disease. Here, we used phage display to identify a novel peptide (SP94), which binds specifically to hepatocellular carcinoma cells. In vitro, the phage clone PC94 was shown to bind to hepato...
متن کاملEnhancing gene delivery of adeno-associated viruses by cell-permeable peptides
Adeno-associated virus type 2 (AAV2) is considered a promising gene delivery vector and has been extensively applied in several disease models; however, inefficient transduction in various cells and tissues has limited its widespread application in many areas of gene therapy. In this study, we have developed a general, but efficient, strategy to enhance viral transduction, both in vitro and in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drug Delivery
سال: 2017
ISSN: 1071-7544,1521-0464
DOI: 10.1080/10717544.2016.1247926